Vesak day is one of only two days in a year i get to use "V" to start a post somewhat normally. the other occasion is - and this goes without saying - vanadium day, where chemists celebrate the discovery of that element and its subsequent use in the contact process for manufacturing sulphuric acid. no, of course i'm kidding. the other day is also known as SAD. i've written about it a while back, in february. you should know what day it is just based on the time reference, if not just the letter V.
research is going relatively smoothly. now that i'm not preoccupied by classes, i'm getting more lab work done. catalyst synthesis is coming along smoothly. NMR showed that i got pure intermediates for both variations of the catalyst, so i'm thankful there. since that looks good, why did i use "relatively"? well, the asymmetric reaction isn't going too well. i'm trying my hand at repeating an already-published reaction, so whatever i write here probably won't be any secret information. the reaction is supposed to give about 98% yield and 90% ee (it's a JACS paper, so it's definitely reliable...even my professor uses that as the benchmark reaction for our group). the first time i did it, i didn't calculate the yield, but got basically racemic product. the second time, my yield sucked. not only that, i didn't get any product at all! the HPLC didn't have peaks at the correct retention times. on the flipside, if i set the HPLC wrongly, my enantioselectivity will be really good because there was only one very significant peak. the weird thing is that the peaks for both runs came out at around 7 minutes. so chances are that they are the same thing. could be that the substrate didn't react. i noticed that my isolated solid didn't really dissolve well in hexane/IPA. but the Rf value is right! unless the substrate has a similar Rf value...which should not be the case, since there's an acid group.
eliminating that possibility, there are still far too many variables. the more significant ones i think are contamination, and poor experimental technique. for contamination, the substrate may contain trace acid due to its synthesis scheme. i've heard that acid messes things up. not only that, my professor had also previously warned me about unclean glassware, spatulas, and other apparatus. i think this is less likely to be the reason, since i cleaned everything before use. only possible source of contamination might be the vacuum lines. if you ask me, i think the most likely issue is with my experimental technique. there are a lot of experimental steps for this one reaction, and mistakes could happen in almost any of them. the more significant ones are probably not maintaining the temperature at -78°C, and not adding the NBS directly into the solution. what really annoys me is that i don't know what exactly went wrong! if my temperature control was poor, the ee should be low. but to not have the correct product based on HPLC...i don't know. should probably run an NMR to see if my product is the correct one, and confirm that my HPLC parameters were set correctly.
wow that was a lot to say for just one experiment. i had initially considered going back today to do some lab work, but hearing that the 300MHz NMR broke down made me decide against that eventually. ok, i'll be the first to admit that that isn't a good enough reason. in fact, it's barely a reason. the NMR breaking down has almost zero effect on my experiments. and even if there was significant effect, i still have access to the 500MHz NMR. it's just a convenient thing that happened at the right time, so i'm using that as a shield. in all honesty though, i wasn't too inclined to go back today, even before knowing about the NMR. there are currently no reactions i can finish within today, and nothing i can set up and leave overnight (too dangerous or bad timing, like i'll have to go in extra-early tomorrow). besides, a day probably doesn't count for much in the grand scheme of things.
as i was closing up the lab and preparing to head home last night/this morning (yes, i stayed late again. damned HPLC), i was doing some thinking. surprisingly in coming-to 11 years of blogging, i don't think i've mentioned this particular bit of trivia about myself yet. for as long as i can remember (after being able to think coherently, of course), my brain has engaged in thought-hopping while it's idle. i suppose that that's a fairly common thing for most people...or at least, it's not unheard of. what makes it unique for me (i think) is that i tend to stray quite far from the original thought. but still, there's some logical connection, so you can see how this leads to that. let's use last night's sequence as an example.
one of my facebook friends shared a post titled,
"The pictures Kim Jong-un DID NOT want you to see: Haunting images from inside North Korea". check it out for yourself, the link's right there. so i started thinking about north korea. *disclaimer: all views here are my own, and may not be reflective of the true situation due to my limited understanding of global politics and most other things in life*. i guess the biggest question is, why doesn't north korea just open up to the world? well, there could be any number of reasons. #1 (and most unlikely): they really think that democracy and the "western" way of life is bad. but if that's the case, how come most western nations are doing better than them economically? and why do people in those same western nations enjoy a higher standard of living, and arguably, quality of life? i mean, you don't see kids in the US, UK, or even in singapore being forced to do hard labour. power disruptions are almost nonexistent here (our last blackout was years ago), education consists of facts, not propaganda that will get you laughed at in any other country, and people have a life outside work, music, games, consumer goods, etc. on the other hand, i guess life is kind of simpler in north korea. do whatever the government tells you, and that's it. not my cup of tea, but i guess it's ok if the people like it. based on the number of defectors and attempted escapes...i doubt that. the other thing i don't get is why north korea wants to put on a show, like having all sorts of good-looking (but useless) buildings near the border. in today's age of satellites and technology, do they seriously think that the world at large can't call their bluff? or maybe the leaders are really that unaware of technological developments.
#2: the leaders are greedy/power-hungry. north korea is basically a family-run country, and has been for the last 50-odd years. asking the leaders to give up power would not go down well, i think. they'd have to learn to live like normal people. and when the people go overseas and see how far behind they've been, that'll lead to a whole other set of issues. i think it's kind of unfair, to deprive generations of people of the chance to fully maximize their potential. tangent thought: humans are basically self-serving, i think. like, if the choice came down to harming either yourself or someone else, most people would harm someone else. call it selfishness, survival instinct, whatever. end result is the same. of course, there ARE people who will sacrifice themselves, but these people are few and far between.
my friend told me about a particular thought experiment some time ago: there's a magic ATM card (or credit card, whichever works). you can use it to pay for whatever expense, no matter how big, but each time you make a transaction, someone in the world (other than yourself, you're immune) dies. it's totally random, so it could be your best friend, or some sick child in africa, basically any one of the 7+ billion people in the world, except you. after the transaction was complete, you'd know who died. would you use the card? if it were me, i'd actually say yes! let's say i know 1000 people by name or by face. out of these 1000 people, let's say that there are 500 of whom i care about and want alive. for each transaction i make, there is a 1 in 14 million chance someone i care about dies (all figures were rounded). those are actually insanely good odds! in the interest of reducing the chance of killing someone i know and like, i think what' i'd do is to make one super huge purchase, like an entire condo development, then rent it out to generate substantial passive income. if i really was
suay enough to kill someone i know, then...i don't know. it's a calculated risk i guess, like most things are in life. the counter-argument would naturally be why even take that risk in the first place? because the payout is ridiculously good. that, along with the high odds of non-failure, mean taking the risk is worth it. but then, the person who dies may be someone powerful, or may have family. or the person may be on death row already. the fundamental question here, i guess, is how much lives are worth, and what gives anyone the authority to take others' lives. more on that later.
why doesn't someone do something about the north korea situation? like, the UN could force north korea to open up, via economic or military action. of course, there would probably be a war, and there'd be casualties all around, so maybe that's not a good idea. i really wonder how the north korean leaders can maintain a clear conscience about messing up so many peoples' lives. it's stupid, i think. at the same time, i can't deny that people MAY want to live under those conditions. so how about this: those who want to leave, leave. those who want to stay, stay. something tells me that only the leaders will be left. and when there's nobody to rule over, there's going to be some reshuffling. but back to the point on forcing. who or what gives any country the right to interfere in another country's administration? the only thing i can think of is if the majority of the people are actively asking for help. scale that down for a bit, and the next question is, what gives a person the right to rule over others? like, what allows a judge to decide how many years' jail a criminal gets, or if the criminal should be hanged? the law, i guess. but who writes the law? how can trafficking over 1g of heroin lead to a loss of life? is there an exchange rate table somewhere? i don't think so. i guess it's how much harm a person does, or could have done. killing someone...sure. a life for a life sounds fair. but what about killing in self-defence, or killing a person who didn't have much longer to live anyway (think harry potter book 6)? so confusing. i'm infinitely grateful that i'm not majoring in law.
a related thought is on leadership. similarly, what gives someone the right to lead others? i guess that would be others choosing to follow that person. i've heard the words "leadership qualities" thrown about all over the place. somehow, it's kind of like an invisible thing. just by observing someone, you'll be able to tell if they'd make a good leader. can we actually define what leadership qualities are? i guess i would define it as how much people are willing to take instructions from you, and how good you are at giving these instructions such that things are done most efficiently. can leadership qualities be taught? well...i think it's both a nature and nurture thing. some people are just born with the charisma, so it's natural for them. of course, it can be learnt, even faked, but natural will have the advantage, i think. as for learning how to effectively use your resources, that's more learnt than inbuilt. some people learn faster than others, though.
ok...maybe this isn't the best example to showcase how my thoughts can lead to unrelated topics. i think that this train of thought was still reasonably easy to follow. then again, i obviously would think so, because it's my train of thought. i'd think that the link between orange juice and a nitrogen gas tank was obvious if i'd made it. guess this is also a look into my thought processes/personal views/decision-making processes. hope you enjoyed it. i usually don't blog this in-depth about my thoughts.
back to stuff that has happened,
kata practice, both this past sunday and today. since grading is over, i've gone back to my usual partner. we're preparing for 2 upcoming competitions, the local SJF
kata championships on 1 june, and the JUA asian
kata championships, held in bangkok in late june. since the SJF decided to only focus on
nage no kata and
ju no kata for the local competition, we're planning to compete in
ju no kata. it's mainly to see how we fare...i don't think my partner is expecting a gold. i sure as hell am not. for the JUA event, we should be doing our usual
katame no kata. that is, if the management allows us to go in the first place. even if they give the green light, the fact that they don't support our
kata means that my partner and i have to pay for everything, from airfare to accommodation, competition fees, and other miscellaneous expenditure. allowing space for safety buffer, total cost is projected to be about $500. nothing i can't afford, but still painful. makes me wonder why we even bother when we don't receive help from up top. there are a few sides to this. if we do well, the federation will capitalize on it for publicity, which i think is kind of unfair since they're trying to profit off something that they didn't want to support in the first place. but having said that, they may decide to give us some help in the future since we have proven ourselves, so it may not be all that bad. if we don't do well, ultimately we suffer, because the federation now has a reason to not support us. on a side, note, i think that there are a few reasons why the other 3
kata are not supported. logistics (more
kata = more medals and time required. easier to focus on fewer
kata), lack of participants (as far as i know, each of the 3
kata has only one pair each in singapore who can perform the respective
kata somewhat decently), and to say something not-so-nice (but true!), singapore lacks qualified judges for some of the
kata. but coming back to our training progress, we have to coordinate the spacing and timing a bit better for
katame no kata. the last 2 sets generally look ok, just the first set (holds) are a bit...sloppy? as much as i dislike that word, it seems to be the best adjective to use here. for
ju no kata, we have the basic form mostly down, but only VERY rough ideas about spacing and absolute positioning. have to seek guidance from the experts when our training dates coincide. nearly forgot to mention how crazy my partner is. he wants to compete in
nage no kata for the local event as well. since i am somewhat unable to put up a good performance (not to mention a tiny bit unwilling to do the
kata), he found another partner for it. then again, he has
kata judge ambitions, so i guess he's working according to plan. i'm just floating along, trying to improve.
man, that was a long post! longest so far this year i think. wonder if i forgot anything. despite the length, there probably a couple of things i left out. but well. i'm sure they can wait until future posts. partially because of
kata practice, and partially because i woke up at 7:30am for aforementioned practice, i'm feeling tired. then shouldn't it be wholly due to
kata practice? whatever. hope i can sleep a little earlier tonight, then i'll go to school early tomorrow to start my LAH reduction and try to find out whether it's a problem with the compound or the HPLC setting.